Hypoglycemic, Insulinotrophic and Cytotoxic Activity of three species of Ganoderma
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Published:
Aug 30, 2007
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Abstract
The crude extracts of Ganoderma lucidum, Ganoderma tropicum and Ganoderma tsugae were studied for insulinotrophic and hypoglycemic activities using rat pancreatic β-cell lines, BRIN-BD11 cells and normal Wistar rats. In an oral glucose tolerance test (OGTT), oral administration of 1 g/kg body weight of the crude extract resulted in a significant reduction in blood glucose in the normal rats. In acute 30 min insulin secretion tests, 1 mg/ml crude extract of all tested Ganoderma evoked a 1 - 4 fold stimulation of insulin secretion from the pancreatic β-cell lines. Of these, G. lucidum showed the highest insulinotrophic activity. In addition, cytotoxicity assay of extracts from G. lucidum, G. tropicum and G. tsugae towards rat pancreatic β-celliines showed half maximal inhibition (IC₅₀) at 200, 100 and 150µg/ml, respectively. These results demonstrated the presence of insulin-releasing and hypoglycemic activity in the crude extracts of G. lucidum, G. tropicum and G. tsugae.
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Saufi Bastami, M., Mohd Bohari, S. P., M.H, W., Noor Wahab, M., Rahmani, A. S., Rajab, N. F., & Hamid, M. (2007). Hypoglycemic, Insulinotrophic and Cytotoxic Activity of three species of Ganoderma. Malaysian Journal of Science, 26(2), 41–46. Retrieved from http://jice.um.edu.my/index.php/MJS/article/view/8054
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